Genotype-by-age interaction and identification of longevity-associated genes from microarray data

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3 Scopus citations


Microarray-based comparisons of long-lived and normal mouse strains represent a promising approach for dissecting the basis of lifespan extension in higher organisms. Recently, Boylston et al. (2006) generated a genome-wide data set that allowed expression levels of Snell (Pit1dw/dw) and Ames (Prop1df/df) long-lived mice to be compared with age-matched control mice across different ages (6-24 months). Longevity-associated genes were identified as those genes exhibiting differential expression between long-lived and normal mice at every age examined. In this communication, an alternative approach to identifying longevity-associated genes is suggested and applied to the data sets considered by Boylston et al. (2006). Longevity-associated genes are defined as those exhibiting significant genotype-by-age interaction with respect to expression levels of long-lived and normal mice, and a total of 63 longevity-associated genes are identified. This approach may lend greater confidence to the inference that expression of identified genes specifically underlies aging differences between long-lived and normal genotypes.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
Issue number2-3
StatePublished - Sep 2007
Externally publishedYes


  • Aging
  • Ames
  • Dwarf
  • Lifespan
  • Microarray
  • Pit1
  • Prop1
  • Snell

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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