Genomic heterogeneity within B/T mixed phenotype acute leukemia in a context of an immunophenotype

Ruifang Zheng; Franklin Fuda; Jeffrey R. Gagan; Olga K. Weinberg; Prasad Koduru; Miguel Cantu; Kathleen Ludwig; Jamie M. Truscott; Robert Collins; Stephen Chung; Yazan F. Madanat; Weina Chen

doi:10.1016/j.lrr.2023.100410

Genomic heterogeneity within B/T mixed phenotype acute leukemia in a context of an immunophenotype

Ruifang Zheng, Franklin Fuda, Jeffrey R. Gagan, Olga K. Weinberg, Prasad Koduru, Miguel Cantu, Kathleen Ludwig, Jamie M. Truscott, Robert Collins, Stephen Chung, Yazan F. Madanat, Weina Chen

Research output: Contribution to journal › Article › peer-review

Abstract

B/T mixed phenotype acute leukemia (MPAL) is a rare aggressive leukemia. Three cases of B/T MPAL were identified with comprehensive immunophenotypic, cytogenetic, and molecular studies. T-lineage predominant B/T MPAL shares a genetic signature with T-ALL whereas B/T lineage co-dominant B/T MPAL lacks such a T-ALL signature. All three patients were treated with lineage-matched-ALL therapy and alive at the last follow-up. Our study is the first to demonstrate molecular heterogeneity within B/T MPAL in a context of an immunophenotype of T-lineage versus B-lineage predominance. The implication of such a phenotype-genotype association on diagnostic classification is briefly discussed.

Original language	English (US)
Article number	100410
Journal	Leukemia Research Reports
Volume	21
DOIs	https://doi.org/10.1016/j.lrr.2023.100410
State	Published - Jan 2024

Keywords

AML
B-ALL
B/T MPAL
Genotype
Immunophenotype
JAK/STAT pathway
Mixed phenotype acute leukemia
NOTCH1
PHF6
RAS pathway
T-ALL

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.lrr.2023.100410

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title = "Genomic heterogeneity within B/T mixed phenotype acute leukemia in a context of an immunophenotype",

abstract = "B/T mixed phenotype acute leukemia (MPAL) is a rare aggressive leukemia. Three cases of B/T MPAL were identified with comprehensive immunophenotypic, cytogenetic, and molecular studies. T-lineage predominant B/T MPAL shares a genetic signature with T-ALL whereas B/T lineage co-dominant B/T MPAL lacks such a T-ALL signature. All three patients were treated with lineage-matched-ALL therapy and alive at the last follow-up. Our study is the first to demonstrate molecular heterogeneity within B/T MPAL in a context of an immunophenotype of T-lineage versus B-lineage predominance. The implication of such a phenotype-genotype association on diagnostic classification is briefly discussed.",

keywords = "AML, B-ALL, B/T MPAL, Genotype, Immunophenotype, JAK/STAT pathway, Mixed phenotype acute leukemia, NOTCH1, PHF6, RAS pathway, T-ALL",

author = "Ruifang Zheng and Franklin Fuda and Gagan, {Jeffrey R.} and Weinberg, {Olga K.} and Prasad Koduru and Miguel Cantu and Kathleen Ludwig and Truscott, {Jamie M.} and Robert Collins and Stephen Chung and Madanat, {Yazan F.} and Weina Chen",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2024",

month = jan,

doi = "10.1016/j.lrr.2023.100410",

language = "English (US)",

volume = "21",

journal = "Leukemia Research Reports",

issn = "2213-0489",

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T1 - Genomic heterogeneity within B/T mixed phenotype acute leukemia in a context of an immunophenotype

AU - Zheng, Ruifang

AU - Fuda, Franklin

AU - Gagan, Jeffrey R.

AU - Weinberg, Olga K.

AU - Koduru, Prasad

AU - Cantu, Miguel

AU - Ludwig, Kathleen

AU - Truscott, Jamie M.

AU - Collins, Robert

AU - Chung, Stephen

AU - Madanat, Yazan F.

AU - Chen, Weina

PY - 2024/1

Y1 - 2024/1

N2 - B/T mixed phenotype acute leukemia (MPAL) is a rare aggressive leukemia. Three cases of B/T MPAL were identified with comprehensive immunophenotypic, cytogenetic, and molecular studies. T-lineage predominant B/T MPAL shares a genetic signature with T-ALL whereas B/T lineage co-dominant B/T MPAL lacks such a T-ALL signature. All three patients were treated with lineage-matched-ALL therapy and alive at the last follow-up. Our study is the first to demonstrate molecular heterogeneity within B/T MPAL in a context of an immunophenotype of T-lineage versus B-lineage predominance. The implication of such a phenotype-genotype association on diagnostic classification is briefly discussed.

AB - B/T mixed phenotype acute leukemia (MPAL) is a rare aggressive leukemia. Three cases of B/T MPAL were identified with comprehensive immunophenotypic, cytogenetic, and molecular studies. T-lineage predominant B/T MPAL shares a genetic signature with T-ALL whereas B/T lineage co-dominant B/T MPAL lacks such a T-ALL signature. All three patients were treated with lineage-matched-ALL therapy and alive at the last follow-up. Our study is the first to demonstrate molecular heterogeneity within B/T MPAL in a context of an immunophenotype of T-lineage versus B-lineage predominance. The implication of such a phenotype-genotype association on diagnostic classification is briefly discussed.

KW - AML

KW - B-ALL

KW - B/T MPAL

KW - Genotype

KW - Immunophenotype

KW - JAK/STAT pathway

KW - Mixed phenotype acute leukemia

KW - NOTCH1

KW - PHF6

KW - RAS pathway

KW - T-ALL

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U2 - 10.1016/j.lrr.2023.100410

DO - 10.1016/j.lrr.2023.100410

M3 - Article

C2 - 38273970

AN - SCOPUS:85182885006

SN - 2213-0489

VL - 21

JO - Leukemia Research Reports

JF - Leukemia Research Reports

M1 - 100410

ER -

Genomic heterogeneity within B/T mixed phenotype acute leukemia in a context of an immunophenotype

Abstract

Keywords

ASJC Scopus subject areas

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