TY - JOUR
T1 - Genetics and molecular pathology of gastric malignancy
T2 - Development of targeted therapies in the era of personalized medicine
AU - Van Ness, Michael
AU - Gregg, Jeffrey
AU - Wang, Jun
AU - Chen, Mingyi
PY - 2012
Y1 - 2012
N2 - Gastric malignancy constitutes a major cause of cancer deaths worldwide. Despite recent advances in surgical techniques combined with neoadjuvant chemotherapy and radiotherapy approaches, patients with advanced disease still have poor outcomes. An emerging understanding of the molecular pathways that characterize cell growth, cell cycle, apoptosis, angiogenesis, invasion and metastasis has provided novel targets in gastric cancer therapy. In this review, recent advances in the understanding of molecular tumorigenesis for common gastric malignancies are discussed. We also briefly review the current targeted therapies in the treatment of gastric malignancies. Practical insights are highlighted including HER2 testing and target therapy in gastric adenocarcinoma, morphologic features and molecular signatures of imatinib-resistance GISTs, and recent investigations aimed at tumor-specific therapy for neuroendocrine tumors.
AB - Gastric malignancy constitutes a major cause of cancer deaths worldwide. Despite recent advances in surgical techniques combined with neoadjuvant chemotherapy and radiotherapy approaches, patients with advanced disease still have poor outcomes. An emerging understanding of the molecular pathways that characterize cell growth, cell cycle, apoptosis, angiogenesis, invasion and metastasis has provided novel targets in gastric cancer therapy. In this review, recent advances in the understanding of molecular tumorigenesis for common gastric malignancies are discussed. We also briefly review the current targeted therapies in the treatment of gastric malignancies. Practical insights are highlighted including HER2 testing and target therapy in gastric adenocarcinoma, morphologic features and molecular signatures of imatinib-resistance GISTs, and recent investigations aimed at tumor-specific therapy for neuroendocrine tumors.
KW - Gastric malignancy
KW - Genetics and molecular pathology
KW - Targeted therapy
UR - http://www.scopus.com/inward/record.url?scp=84995740348&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84995740348&partnerID=8YFLogxK
U2 - 10.3978/j.issn.2078-6891.2012.017
DO - 10.3978/j.issn.2078-6891.2012.017
M3 - Review article
C2 - 22943015
AN - SCOPUS:84995740348
SN - 2078-6891
VL - 3
SP - 243
EP - 250
JO - Journal of Gastrointestinal Oncology
JF - Journal of Gastrointestinal Oncology
IS - 3
ER -