TY - JOUR
T1 - Genetically encoded tools for measuring and manipulating metabolism
AU - Choe, Mangyu
AU - Titov, Denis V.
N1 - Publisher Copyright:
© 2022, Springer Nature America, Inc.
PY - 2022/5
Y1 - 2022/5
N2 - Over the past few years, we have seen an explosion of novel genetically encoded tools for measuring and manipulating metabolism in live cells and animals. Here, we will review the genetically encoded tools that are available, describe how these tools can be used and outline areas where future development is needed in this fast-paced field. We will focus on tools for direct measurement and manipulation of metabolites. Metabolites are master regulators of metabolism and physiology through their action on metabolic enzymes, signaling enzymes, ion channels and transcription factors, among others. We hope that this Perspective will encourage more people to use these novel reagents or even join this exciting new field to develop novel tools for measuring and manipulating metabolism. [Figure not available: see fulltext.]
AB - Over the past few years, we have seen an explosion of novel genetically encoded tools for measuring and manipulating metabolism in live cells and animals. Here, we will review the genetically encoded tools that are available, describe how these tools can be used and outline areas where future development is needed in this fast-paced field. We will focus on tools for direct measurement and manipulation of metabolites. Metabolites are master regulators of metabolism and physiology through their action on metabolic enzymes, signaling enzymes, ion channels and transcription factors, among others. We hope that this Perspective will encourage more people to use these novel reagents or even join this exciting new field to develop novel tools for measuring and manipulating metabolism. [Figure not available: see fulltext.]
UR - http://www.scopus.com/inward/record.url?scp=85129023471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85129023471&partnerID=8YFLogxK
U2 - 10.1038/s41589-022-01012-8
DO - 10.1038/s41589-022-01012-8
M3 - Article
C2 - 35484256
AN - SCOPUS:85129023471
SN - 1552-4450
VL - 18
SP - 451
EP - 460
JO - Nature chemical biology
JF - Nature chemical biology
IS - 5
ER -