TY - JOUR
T1 - Genetic changes in the pathogenesis of lung cancer
AU - Birrer, M. J.
AU - Minna, J. D.
PY - 1989
Y1 - 1989
N2 - Human lung cancer is a complex genetic disease resulting from a series of inherited and somatically occurring defects in a number of critical genes. These genetic events, produced in part by carcinogen exposure, include chromosomal deletion, rearrangement, and mutation, and lead to inactivation or activation of certain target genes. Recent data showed these genes to include both recessive oncogenes such as the retinoblastoma gene and dominantly acting oncogenes such as the myc and ras family members.
AB - Human lung cancer is a complex genetic disease resulting from a series of inherited and somatically occurring defects in a number of critical genes. These genetic events, produced in part by carcinogen exposure, include chromosomal deletion, rearrangement, and mutation, and lead to inactivation or activation of certain target genes. Recent data showed these genes to include both recessive oncogenes such as the retinoblastoma gene and dominantly acting oncogenes such as the myc and ras family members.
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U2 - 10.1146/annurev.me.40.020189.001513
DO - 10.1146/annurev.me.40.020189.001513
M3 - Review article
C2 - 2658754
AN - SCOPUS:0024391353
SN - 0066-4219
VL - 40
SP - 305
EP - 317
JO - Annual review of medicine
JF - Annual review of medicine
ER -