Genetic changes in the pathogenesis of lung cancer

M. J. Birrer, J. D. Minna

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Human lung cancer is a complex genetic disease resulting from a series of inherited and somatically occurring defects in a number of critical genes. These genetic events, produced in part by carcinogen exposure, include chromosomal deletion, rearrangement, and mutation, and lead to inactivation or activation of certain target genes. Recent data showed these genes to include both recessive oncogenes such as the retinoblastoma gene and dominantly acting oncogenes such as the myc and ras family members.

Original languageEnglish (US)
Pages (from-to)305-317
Number of pages13
JournalAnnual review of medicine
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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