Abstract
The genes and genomic regulation involved in male genital tract development, gonadal development, and function including those related to spermatogenesis have been implicated as causal factors in male infertility. It has been estimated that genetic abnormalities may account for 15-30% of male factor infertility. As many of the genetic factors are elucidated, more and more information will become relevant to daily clinical applications. Thus, it is essential to appraise the current genetic basis of male reproductive system disorders to help guide the future use of genetic treatments for male infertility.
| Original language | English (US) |
|---|---|
| Title of host publication | Male Infertility |
| Subtitle of host publication | Contemporary Clinical Approaches, Andrology, ART and Antioxidants: Second Edition |
| Publisher | Springer International Publishing |
| Pages | 147-164 |
| Number of pages | 18 |
| ISBN (Electronic) | 9783030323004 |
| ISBN (Print) | 9783030322991 |
| DOIs | |
| State | Published - Jan 1 2020 |
| Externally published | Yes |
Keywords
- Artificial gametes
- Genetics in male infertility
- Genomic regulation of male sexual development
- Hypospadias
- Male genital tract development
- Sertoli cells
- Spermatogenesis
- Spermatogenic genes
- Testis formation
ASJC Scopus subject areas
- General Health Professions
- General Medicine