Genetic and molecular mapping of the Hmt region of mouse

S. Richards; M. Bucan; K. Brorson; M. C. Kiefer; S. W. Hunt; H. Lehrach; K. Fischer Lindahl

doi:10.1002/j.1460-2075.1989.tb08551.x

Genetic and molecular mapping of the Hmt region of mouse

S. Richards, M. Bucan, K. Brorson, M. C. Kiefer, S. W. Hunt, H. Lehrach, K. Fischer Lindahl

Immunology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.

Original language	English (US)
Pages (from-to)	3749-3757
Number of pages	9
Journal	EMBO Journal
Volume	8
Issue number	12
DOIs	https://doi.org/10.1002/j.1460-2075.1989.tb08551.x
State	Published - 1989

Keywords

MHC class I genes
genome organization
maternally transmitted antigen (Mta)
mouse chromosome 17
t-complex

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.1002/j.1460-2075.1989.tb08551.x

Cite this

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abstract = "We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.",

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doi = "10.1002/j.1460-2075.1989.tb08551.x",

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T1 - Genetic and molecular mapping of the Hmt region of mouse

AU - Richards, S.

AU - Bucan, M.

AU - Brorson, K.

AU - Kiefer, M. C.

AU - Hunt, S. W.

AU - Lehrach, H.

AU - Fischer Lindahl, K.

PY - 1989

Y1 - 1989

N2 - We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.

AB - We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.

KW - MHC class I genes

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KW - mouse chromosome 17

KW - t-complex

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Genetic and molecular mapping of the Hmt region of mouse

Abstract

Keywords

ASJC Scopus subject areas

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