Generalized chorea in an infant with semilobar holoprosencephaly

Elan D. Louis, Timothy Lynch, Abba L. Cargan, Stanley Fahn

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We report chorea in an infant with holoprosencephaly. Congenital structural brain disease has not been a reported cause of chorea. Cranial magnetic resonance imaging revealed small, fused frontal lobes with hypoplastic caudates. Our patient responded to symptomatic treatment with dopamine-depleting agents. It is likely that the mechanism for the chorea was a dysfunction of the striatum. The differential diagnosis of childhood chorea should include holoprosencephaly.

Original languageEnglish (US)
Pages (from-to)355-357
Number of pages3
JournalPediatric Neurology
Issue number4
StatePublished - Nov 1995
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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