General synthesis of pyrido[1,2-a]indoles via Pd-catalyzed cyclization of o-picolylbromoarenes

Padon Chuentragool, Zhou Li, Katrina Randle, Faraj Mahchi, Ishmael Ochir, Shadi Assaf, Vladimir Gevorgyan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


An efficient Pd-catalyzed cyclization of o-picolylbromoarenes into pyridoindoles has been developed. This novel transformation, which proceeds through a not common for Pd catalysis L-to X-type pyridine ligand swap, provides an efficient route to aryl-, as well as to cyanopyrido[1,2-a]indoles, not easily accessible by existing cyclization methods.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalJournal of Organometallic Chemistry
StatePublished - Jul 15 2018
Externally publishedYes


  • Cyanopyridoindole
  • C–N coupling
  • Palladium-catalyzed
  • Picolyl L-X-type ligand
  • pyrido[1,2-a]indole

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry


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