Abstract
A general highly regio- and stereoselective palladium-catalyzed head-to-head dimerization reaction of terminal acetylenes is presented. This methodology allows for the efficient synthesis of a variety of 1,4-enynes as single E stereoisomers. Computational studies reveal that this dimerization reaction proceeds via the hydropalladation pathway.
Original language | English (US) |
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Pages (from-to) | 2846-2849 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 14 |
Issue number | 11 |
DOIs | |
State | Published - Jun 1 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry