General and efficient copper-catalyzed three-component coupling reaction towards imidazoheterocycles: One-pot synthesis of alpidem and zolpidem

Natalia Chernyak; Vladimir Gevorgyan

doi:10.1002/anie.200907291

General and efficient copper-catalyzed three-component coupling reaction towards imidazoheterocycles: One-pot synthesis of alpidem and zolpidem

Natalia Chernyak, Vladimir Gevorgyan

Research output: Contribution to journal › Article › peer-review

398 Scopus citations

Abstract

(Figure Presented) Three is not a crowd: A method for the construction of Imidazopyridine, imidazoquinoline, and imidazoisoquinoline frameworks has been developed. The synthetic utility of this method was demonstrated in a highly efficient one-pot synthesis of the drugs alpidem and Zolpidem (see scheme).

Original language	English (US)
Pages (from-to)	2743-2746
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	15
DOIs	https://doi.org/10.1002/anie.200907291
State	Published - Apr 1 2010
Externally published	Yes

Keywords

Cyclization
Heterocycles
Homogeneous catalysis
Imidazopyridines
Multicomponent reactions

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200907291

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abstract = "(Figure Presented) Three is not a crowd: A method for the construction of Imidazopyridine, imidazoquinoline, and imidazoisoquinoline frameworks has been developed. The synthetic utility of this method was demonstrated in a highly efficient one-pot synthesis of the drugs alpidem and Zolpidem (see scheme).",

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AU - Gevorgyan, Vladimir

PY - 2010/4/1

Y1 - 2010/4/1

N2 - (Figure Presented) Three is not a crowd: A method for the construction of Imidazopyridine, imidazoquinoline, and imidazoisoquinoline frameworks has been developed. The synthetic utility of this method was demonstrated in a highly efficient one-pot synthesis of the drugs alpidem and Zolpidem (see scheme).

AB - (Figure Presented) Three is not a crowd: A method for the construction of Imidazopyridine, imidazoquinoline, and imidazoisoquinoline frameworks has been developed. The synthetic utility of this method was demonstrated in a highly efficient one-pot synthesis of the drugs alpidem and Zolpidem (see scheme).

KW - Cyclization

KW - Heterocycles

KW - Homogeneous catalysis

KW - Imidazopyridines

KW - Multicomponent reactions

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General and efficient copper-catalyzed three-component coupling reaction towards imidazoheterocycles: One-pot synthesis of alpidem and zolpidem

Abstract

Keywords

ASJC Scopus subject areas

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