Abstract
Purpose of Review: This review provides the otolaryngology community with background on the basics of gene therapy for congenital hearing loss along with potential frontiers in this field. Recent Findings: In the last several years, there has been a tremendous increase in the amount of basic science research in gene therapy models for sensorineural hearing loss. Most work has been limited to murine models, but the transition to nonhuman primates has also occurred. There are still concerns with identifying the proper viral capsids, developing the most effective delivery approach, and timing the injection in humans to adequately restore hearing capability. Summary: Despite a growing interest and rapid advancement of the gene therapy research, there are still several challenges that remain before this can be utilized for children with congenital hearing loss.
Original language | English (US) |
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Pages (from-to) | 357-364 |
Number of pages | 8 |
Journal | Current Otorhinolaryngology Reports |
Volume | 10 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2022 |
Keywords
- Adeno-associated virus
- Congenital hearing loss
- Gene therapy
ASJC Scopus subject areas
- Surgery
- Immunology and Allergy
- Otorhinolaryngology
- Clinical Neurology