GEC1, a protein related to GABARAP, interacts with tubulin and GABA A receptor

Virginie Mansuy, Wilfrid Boireau, Annick Fraichard, Jean Luc Schlick, Michèle Jouvenot, Régis Delage-Mourroux

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


We have previously identified in uterine cells a novel estrogen-regulated gene called gec1. GEC1 presents 87% identity with GABARAP which, so far, was the only protein found to associate with tubulin and GABA A receptor. We demonstrated then that GEC1 interacts in vitro with tubulin and GABA A receptor, and promotes tubulin assembly and microtubule bundling. Since all polyclonal antibodies failed in discrimination of both proteins GEC1 and GABARAP, a GEC1-GFP fusion protein was used to specifically localize GEC1. GEC1-GFP was distributed over the cytoplasm in perinuclear vesicles with a scattered pattern. Overall, our data show that GEC1 could be a new member of the GABARAP family involved in the transport of GABA A receptor.

Original languageEnglish (US)
Pages (from-to)639-648
Number of pages10
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Dec 10 2004


  • Biacore
  • GEC1
  • GST-pull-down
  • Protein trafficking
  • Protein-protein interaction

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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