Gating Immunity and Death at the Nuclear Pore Complex

Mary Dasso; Beatriz M A Fontoura

doi:10.1016/j.cell.2016.08.026

Gating Immunity and Death at the Nuclear Pore Complex

Mary Dasso, Beatriz M A Fontoura

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

The nuclear pore complex is the primary conduit for nuclear import and export of molecules. In this issue, Gu et al. uncover a novel mechanism in which immune signaling and programmed cell death require nuclear pore rearrangement and release of sequestered cyclin-dependent kinase inhibitors to elicit immunity and death.

Original language	English (US)
Pages (from-to)	1364-1366
Number of pages	3
Journal	Cell
Volume	166
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2016.08.026
State	Published - Sep 8 2016

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2016.08.026

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title = "Gating Immunity and Death at the Nuclear Pore Complex",

abstract = "The nuclear pore complex is the primary conduit for nuclear import and export of molecules. In this issue, Gu et al. uncover a novel mechanism in which immune signaling and programmed cell death require nuclear pore rearrangement and release of sequestered cyclin-dependent kinase inhibitors to elicit immunity and death.",

author = "Mary Dasso and Fontoura, {Beatriz M A}",

note = "Funding Information: We thank Angela Diehl for the illustration. M.D. is supported through NICHD Intramural Project #Z01 HD008954. B.M.A.F. is supported by: NIH R01 GM113874-01; R01AI125524-01; and R21 AI119304-01. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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AU - Dasso, Mary

AU - Fontoura, Beatriz M A

N1 - Funding Information: We thank Angela Diehl for the illustration. M.D. is supported through NICHD Intramural Project #Z01 HD008954. B.M.A.F. is supported by: NIH R01 GM113874-01; R01AI125524-01; and R21 AI119304-01. Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/9/8

Y1 - 2016/9/8

N2 - The nuclear pore complex is the primary conduit for nuclear import and export of molecules. In this issue, Gu et al. uncover a novel mechanism in which immune signaling and programmed cell death require nuclear pore rearrangement and release of sequestered cyclin-dependent kinase inhibitors to elicit immunity and death.

AB - The nuclear pore complex is the primary conduit for nuclear import and export of molecules. In this issue, Gu et al. uncover a novel mechanism in which immune signaling and programmed cell death require nuclear pore rearrangement and release of sequestered cyclin-dependent kinase inhibitors to elicit immunity and death.

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M3 - Short survey

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VL - 166

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JO - Cell

JF - Cell

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ER -

Gating Immunity and Death at the Nuclear Pore Complex

Abstract

ASJC Scopus subject areas

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