Gastrointestinal sensitivity and gastroesophageal reflux disease

Annamaria Altomare, Michele Pier Luca Guarino (Sara Emerenziani), Michele Cicala, Asbjørn Mohr Drewes, Anne Lund Krarup, Christina Brock, Christian Lottrup, Jens Brøndum Frøkjær, Rhonda F. Souza, Gerardo Nardone, Debora Compare

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


This paper reports on gastrointestinal sensitivity, including on the role of refluxate volume on the perception of reflux symptoms; experimental pain models that mimic mechanisms and symptoms of pain associated with esophageal diseases; the potential role of the acid receptor TRPV1 in the genesis of gastroesophageal reflux disease (GERD) symptoms; and roles for ATP and the purine and pyrimidine receptor subfamilies P1, P2X, and P2Y in the pathogenesis of GERD symptoms.

Original languageEnglish (US)
Pages (from-to)80-95
Number of pages16
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Oct 2013


  • ATP
  • GERD
  • PAR2
  • Pain
  • Purinergic receptors
  • TRPV1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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