Gastrointestinal sensitivity and gastroesophageal reflux disease

Annamaria Altomare; Michele Pier Luca Guarino (Sara Emerenziani); Michele Cicala; Asbjørn Mohr Drewes; Anne Lund Krarup; Christina Brock; Christian Lottrup; Jens Brøndum Frøkjær; Rhonda F. Souza; Gerardo Nardone; Debora Compare

doi:10.1111/nyas.12236

Gastrointestinal sensitivity and gastroesophageal reflux disease

Annamaria Altomare, Michele Pier Luca Guarino (Sara Emerenziani), Michele Cicala, Asbjørn Mohr Drewes, Anne Lund Krarup, Christina Brock, Christian Lottrup, Jens Brøndum Frøkjær, Rhonda F. Souza, Gerardo Nardone, Debora Compare

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

This paper reports on gastrointestinal sensitivity, including on the role of refluxate volume on the perception of reflux symptoms; experimental pain models that mimic mechanisms and symptoms of pain associated with esophageal diseases; the potential role of the acid receptor TRPV1 in the genesis of gastroesophageal reflux disease (GERD) symptoms; and roles for ATP and the purine and pyrimidine receptor subfamilies P1, P2X, and P2Y in the pathogenesis of GERD symptoms.

Original language	English (US)
Pages (from-to)	80-95
Number of pages	16
Journal	Annals of the New York Academy of Sciences
Volume	1300
Issue number	1
DOIs	https://doi.org/10.1111/nyas.12236
State	Published - Oct 2013

Keywords

ATP
GERD
PAR2
Pain
Purinergic receptors
TRPV1

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/nyas.12236

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abstract = "This paper reports on gastrointestinal sensitivity, including on the role of refluxate volume on the perception of reflux symptoms; experimental pain models that mimic mechanisms and symptoms of pain associated with esophageal diseases; the potential role of the acid receptor TRPV1 in the genesis of gastroesophageal reflux disease (GERD) symptoms; and roles for ATP and the purine and pyrimidine receptor subfamilies P1, P2X, and P2Y in the pathogenesis of GERD symptoms.",

keywords = "ATP, GERD, PAR2, Pain, Purinergic receptors, TRPV1",

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AU - Altomare, Annamaria

AU - Luca Guarino (Sara Emerenziani), Michele Pier

AU - Cicala, Michele

AU - Drewes, Asbjørn Mohr

AU - Krarup, Anne Lund

AU - Brock, Christina

AU - Lottrup, Christian

AU - Frøkjær, Jens Brøndum

AU - Souza, Rhonda F.

AU - Nardone, Gerardo

AU - Compare, Debora

PY - 2013/10

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AB - This paper reports on gastrointestinal sensitivity, including on the role of refluxate volume on the perception of reflux symptoms; experimental pain models that mimic mechanisms and symptoms of pain associated with esophageal diseases; the potential role of the acid receptor TRPV1 in the genesis of gastroesophageal reflux disease (GERD) symptoms; and roles for ATP and the purine and pyrimidine receptor subfamilies P1, P2X, and P2Y in the pathogenesis of GERD symptoms.

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KW - Pain

KW - Purinergic receptors

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Gastrointestinal sensitivity and gastroesophageal reflux disease

Abstract

Keywords

ASJC Scopus subject areas

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