Gabapentin suppresses cortical spreading depression susceptibility

Ulrike Hoffmann; Ergin Dileköz; Chiho Kudo; Cenk Ayata

doi:10.1038/jcbfm.2010.92

Gabapentin suppresses cortical spreading depression susceptibility

Ulrike Hoffmann, Ergin Dileköz, Chiho Kudo, Cenk Ayata

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca _v 2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca _v 2.1 through high-affinity binding to its α 2 subunit, on CSD susceptibility in anesthetized rats. Gabapentin, 100 or 200 mg/kg, elevated the electrical threshold for CSD and diminished recurrent CSDs evoked by topical KCl, when administered 1 hour before testing. With its favorable safety and tolerability profile, gabapentin may have a role in suppression of injury depolarizations in stroke, intracranial hemorrhage, and traumatic brain injury.

Original language	English (US)
Pages (from-to)	1588-1592
Number of pages	5
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	30
Issue number	9
DOIs	https://doi.org/10.1038/jcbfm.2010.92
State	Published - Sep 2010
Externally published	Yes

Keywords

cortex
electrophysiology
gabapentin
rat
spreading depression

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/jcbfm.2010.92

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Gabapentin suppresses cortical spreading depression susceptibility

Abstract

Keywords

ASJC Scopus subject areas

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