TY - JOUR
T1 - GABAergic transmission in temporal lobe epilepsy
T2 - The role of neurosteroids
AU - Joshi, Suchitra
AU - Rajasekaran, Karthik
AU - Kapur, Jaideep
PY - 2013/6
Y1 - 2013/6
N2 - Modification of GABAergic inhibition is an intensely investigated hypothesis guiding research into mechanisms underlying temporal lobe epilepsy (TLE). Seizures can be initiated by blocking γ amino butyric acid type A (GABAA receptors, GABARs), which mediate fast synaptic inhibition in the brain, and controlled by drugs that enhance their function. Derivatives of steroid hormones called neurosteroids are natural substances that physiologically enhance GABAR function and suppress seizures. GABAR structure, function, expression, assembly, and pharmacological properties are changed in the hippocampus of epileptic animals. These alterations render GABARs less sensitive to neurosteroid modulation, which may contribute to seizure susceptibility. Plasticity of GABARs could play a role in periodic exacerbation of seizures experienced by women with epilepsy, commonly referred to as catamenial epilepsy.
AB - Modification of GABAergic inhibition is an intensely investigated hypothesis guiding research into mechanisms underlying temporal lobe epilepsy (TLE). Seizures can be initiated by blocking γ amino butyric acid type A (GABAA receptors, GABARs), which mediate fast synaptic inhibition in the brain, and controlled by drugs that enhance their function. Derivatives of steroid hormones called neurosteroids are natural substances that physiologically enhance GABAR function and suppress seizures. GABAR structure, function, expression, assembly, and pharmacological properties are changed in the hippocampus of epileptic animals. These alterations render GABARs less sensitive to neurosteroid modulation, which may contribute to seizure susceptibility. Plasticity of GABARs could play a role in periodic exacerbation of seizures experienced by women with epilepsy, commonly referred to as catamenial epilepsy.
KW - GABA-A receptors
KW - Neurosteroids
KW - Pharmacology
KW - Physiology
KW - Temporal lobe epilepsy
KW - Trafficking
UR - http://www.scopus.com/inward/record.url?scp=84877610548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877610548&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2011.10.028
DO - 10.1016/j.expneurol.2011.10.028
M3 - Review article
C2 - 22101060
AN - SCOPUS:84877610548
SN - 0014-4886
VL - 244
SP - 36
EP - 42
JO - Experimental Neurology
JF - Experimental Neurology
ER -