Future Biologic Treatments for Perthes Disease

David G. Little, Harry K W Kim

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Standard surgical approaches for Perthes disease consist of nonoperative physical treatments or surgical treatment. Several investigators have been working on a better understanding of the pathophysiology and pathobiology of Perthes disease. Most of the focus has been on antiresorptive treatments. Other treatment avenues, however, include controlling the inflammatory phase of Perthes disease, increasing revascularization of necrotic bone, and anabolic strategies to increase bone formation. This article presents a current pathophysiological model of Perthes disease, reviews experimental strategies in pharmaceutical treatments, and suggests future areas for research.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalOrthopedic Clinics of North America
Issue number3
StatePublished - Jul 2011


  • Biologic interventions
  • Experimental strategies
  • Perthes disease

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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