TY - JOUR
T1 - Furazolidone and Quinacrine
T2 - Comparative Study of Therapy for Giardiasis in Children
AU - Craft, J. C.
AU - Murphy, T.
AU - Nelson, J. D.
PY - 1981/2
Y1 - 1981/2
N2 - Furazolidone and quinacrine hydrochloride were compared for efficacy, toxicity, and ease of administration in 45 young children with giardiasis. With the initial course of therapy, the cure rate was 89% (17/19) with furazolidone and with quinacrine it was 64% (9/14) in children less than 5 years and 92% (11/12) in older children. Cure rates for all courses of therapy were 92% (24/26) with furazolidone and 53% (9/17) and 92% (12/13) in the younger and older children, respectively, treated with quinacrine. Quinacrine failure was usually due to severe vomiting. When re-treated with furazolidone, patients were cured. The disadvantages of furazolidone are the large volume of doses and the expense. In this study, furazolidone was more effective and better tolerated than quinacrine for the treatment of giardiasis.
AB - Furazolidone and quinacrine hydrochloride were compared for efficacy, toxicity, and ease of administration in 45 young children with giardiasis. With the initial course of therapy, the cure rate was 89% (17/19) with furazolidone and with quinacrine it was 64% (9/14) in children less than 5 years and 92% (11/12) in older children. Cure rates for all courses of therapy were 92% (24/26) with furazolidone and 53% (9/17) and 92% (12/13) in the younger and older children, respectively, treated with quinacrine. Quinacrine failure was usually due to severe vomiting. When re-treated with furazolidone, patients were cured. The disadvantages of furazolidone are the large volume of doses and the expense. In this study, furazolidone was more effective and better tolerated than quinacrine for the treatment of giardiasis.
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U2 - 10.1001/archpedi.1981.02130260056016
DO - 10.1001/archpedi.1981.02130260056016
M3 - Article
C2 - 7468550
AN - SCOPUS:0019378759
SN - 0096-8994
VL - 135
SP - 164
EP - 166
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 2
ER -