Functional imaging of working memory and peripheral endothelial function in middle-aged adults

Mitzi M. Gonzales; Takashi Tarumi; Hirofumi Tanaka; Jun Sugawara; Tali Swann-Sternberg; Katayoon Goudarzi; Andreana P. Haley

doi:10.1016/j.bandc.2010.04.007

Functional imaging of working memory and peripheral endothelial function in middle-aged adults

Mitzi M. Gonzales, Takashi Tarumi, Hirofumi Tanaka, Jun Sugawara, Tali Swann-Sternberg, Katayoon Goudarzi, Andreana P. Haley

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (β=0.338, p=0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5, 36)=2.66, p=0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted.

Original language	English (US)
Pages (from-to)	146-151
Number of pages	6
Journal	Brain and Cognition
Volume	73
Issue number	2
DOIs	https://doi.org/10.1016/j.bandc.2010.04.007
State	Published - Jul 2010

Keywords

Cardiovascular disease
Cognition
Endothelium
Magnetic resonance imaging
Middle-aged
Working memory

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Experimental and Cognitive Psychology
Developmental and Educational Psychology
Arts and Humanities (miscellaneous)
Cognitive Neuroscience

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10.1016/j.bandc.2010.04.007

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title = "Functional imaging of working memory and peripheral endothelial function in middle-aged adults",

abstract = "The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (β=0.338, p=0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5, 36)=2.66, p=0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted.",

keywords = "Cardiovascular disease, Cognition, Endothelium, Magnetic resonance imaging, Middle-aged, Working memory",

author = "Gonzales, {Mitzi M.} and Takashi Tarumi and Hirofumi Tanaka and Jun Sugawara and Tali Swann-Sternberg and Katayoon Goudarzi and Haley, {Andreana P.}",

note = "Funding Information: This work was funded by NINR center Grant P30 NR005051 (APH), AHA Grant 09BGIA2060722 (APH) and the University of Texas at Austin (APH). The authors thank the UT Imaging Center staff for their help with the participants.",

year = "2010",

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language = "English (US)",

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AU - Tarumi, Takashi

AU - Tanaka, Hirofumi

AU - Sugawara, Jun

AU - Swann-Sternberg, Tali

AU - Goudarzi, Katayoon

AU - Haley, Andreana P.

N1 - Funding Information: This work was funded by NINR center Grant P30 NR005051 (APH), AHA Grant 09BGIA2060722 (APH) and the University of Texas at Austin (APH). The authors thank the UT Imaging Center staff for their help with the participants.

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N2 - The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (β=0.338, p=0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5, 36)=2.66, p=0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted.

AB - The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (β=0.338, p=0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5, 36)=2.66, p=0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted.

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Functional imaging of working memory and peripheral endothelial function in middle-aged adults

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Keywords

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