Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: Implications for diverging melanocortin pathways

Jong Woo Sohn; Kevin W. Williams

doi:10.1007/s12035-012-8240-6

Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: Implications for diverging melanocortin pathways

Jong Woo Sohn, Kevin W. Williams

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons are essential regulators of food intake, energy expenditure, and glucose homeostasis. POMC neurons integrate several key metabolic signals that include neurotransmitters and hormones. The change in activity of POMC neurons is relayed to melanocortin receptors in distinct regions of the central nervous system. This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis.

Original language	English (US)
Pages (from-to)	225-233
Number of pages	9
Journal	Molecular Neurobiology
Volume	45
Issue number	2
DOIs	https://doi.org/10.1007/s12035-012-8240-6
State	Published - Apr 2012

Keywords

Adiposity
Body weight
Energy expenditure
Hyperglycemia
Insulin
Leptin
Melanocortin
PI3K
Segregation
Serotonin
TRPC

ASJC Scopus subject areas

Neurology
Cellular and Molecular Neuroscience

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10.1007/s12035-012-8240-6

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title = "Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: Implications for diverging melanocortin pathways",

abstract = "Arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons are essential regulators of food intake, energy expenditure, and glucose homeostasis. POMC neurons integrate several key metabolic signals that include neurotransmitters and hormones. The change in activity of POMC neurons is relayed to melanocortin receptors in distinct regions of the central nervous system. This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis.",

keywords = "Adiposity, Body weight, Energy expenditure, Hyperglycemia, Insulin, Leptin, Melanocortin, PI3K, Segregation, Serotonin, TRPC",

author = "Sohn, {Jong Woo} and Williams, {Kevin W.}",

note = "Funding Information: Acknowledgments We gratefully acknowledge Joel K. Elmquist D.V. M, Ph.D. for insightful comments on this review. This work was supported by the American Diabetes Association (7-11-MN-16) to J.-W.S. and the National Institutes of Health (K01 DK087780) to KWW.",

year = "2012",

month = apr,

doi = "10.1007/s12035-012-8240-6",

language = "English (US)",

volume = "45",

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journal = "Molecular Neurobiology",

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T2 - Implications for diverging melanocortin pathways

AU - Sohn, Jong Woo

AU - Williams, Kevin W.

N1 - Funding Information: Acknowledgments We gratefully acknowledge Joel K. Elmquist D.V. M, Ph.D. for insightful comments on this review. This work was supported by the American Diabetes Association (7-11-MN-16) to J.-W.S. and the National Institutes of Health (K01 DK087780) to KWW.

PY - 2012/4

Y1 - 2012/4

N2 - Arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons are essential regulators of food intake, energy expenditure, and glucose homeostasis. POMC neurons integrate several key metabolic signals that include neurotransmitters and hormones. The change in activity of POMC neurons is relayed to melanocortin receptors in distinct regions of the central nervous system. This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis.

AB - Arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons are essential regulators of food intake, energy expenditure, and glucose homeostasis. POMC neurons integrate several key metabolic signals that include neurotransmitters and hormones. The change in activity of POMC neurons is relayed to melanocortin receptors in distinct regions of the central nervous system. This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis.

KW - Adiposity

KW - Body weight

KW - Energy expenditure

KW - Hyperglycemia

KW - Insulin

KW - Leptin

KW - Melanocortin

KW - PI3K

KW - Segregation

KW - Serotonin

KW - TRPC

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DO - 10.1007/s12035-012-8240-6

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JF - Molecular Neurobiology

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Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: Implications for diverging melanocortin pathways

Abstract

Keywords

ASJC Scopus subject areas

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