TY - JOUR
T1 - Functional genomics and systems biology in human neuroscience
AU - Konopka, Genevieve
AU - Bhaduri, Aparna
N1 - Publisher Copyright:
© 2023, Springer Nature Limited.
PY - 2023/11/9
Y1 - 2023/11/9
N2 - Neuroscience research has entered a phase of key discoveries in the realm of neurogenomics owing to strong financial and intellectual support for resource building and tool development. The previous challenge of tissue heterogeneity has been met with the application of techniques that can profile individual cells at scale. Moreover, the ability to perturb genes, gene regulatory elements and neuronal activity in a cell-type-specific manner has been integrated with gene expression studies to uncover the functional underpinnings of the genome at a systems level. Although these insights have necessarily been grounded in model systems, we now have the opportunity to apply these approaches in humans and in human tissue, thanks to advances in human genetics, brain imaging and tissue collection. We acknowledge that there will probably always be limits to the extent to which we can apply the genomic tools developed in model systems to human neuroscience; however, as we describe in this Perspective, the neuroscience field is now primed with an optimal foundation for tackling this ambitious challenge. The application of systems-level network analyses to these datasets will facilitate a deeper appreciation of human neurogenomics that cannot otherwise be achieved from directly observable phenomena.
AB - Neuroscience research has entered a phase of key discoveries in the realm of neurogenomics owing to strong financial and intellectual support for resource building and tool development. The previous challenge of tissue heterogeneity has been met with the application of techniques that can profile individual cells at scale. Moreover, the ability to perturb genes, gene regulatory elements and neuronal activity in a cell-type-specific manner has been integrated with gene expression studies to uncover the functional underpinnings of the genome at a systems level. Although these insights have necessarily been grounded in model systems, we now have the opportunity to apply these approaches in humans and in human tissue, thanks to advances in human genetics, brain imaging and tissue collection. We acknowledge that there will probably always be limits to the extent to which we can apply the genomic tools developed in model systems to human neuroscience; however, as we describe in this Perspective, the neuroscience field is now primed with an optimal foundation for tackling this ambitious challenge. The application of systems-level network analyses to these datasets will facilitate a deeper appreciation of human neurogenomics that cannot otherwise be achieved from directly observable phenomena.
UR - http://www.scopus.com/inward/record.url?scp=85176043724&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85176043724&partnerID=8YFLogxK
U2 - 10.1038/s41586-023-06686-1
DO - 10.1038/s41586-023-06686-1
M3 - Article
C2 - 37938705
AN - SCOPUS:85176043724
SN - 0028-0836
VL - 623
SP - 274
EP - 282
JO - Nature
JF - Nature
IS - 7986
ER -