I have tried to show how the anabolic/catabolic cycle is regulated by modest changes in the glucagon insulin ratio. Although the metabolic changes induced are profound and the biochemical alterations complicated, they likely flow primarily from regulation of a single intermediate. fructose-2.6-bisphosphate, which in turn determines flux over the glycolytic/gluconeogenic pathways and thereby also controls hepatic lipid metabolism and ketogenesis. If these interpretations prove correct it is an attractive and cohesive system. I thank the American Diabetes Association for giving me the Banting Medal.
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism