TY - JOUR
T1 - Frenemies
T2 - Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions
AU - Cameron, Elizabeth A.
AU - Sperandio, Vanessa
N1 - Funding Information:
Work in the V.S. laboratory is supported by the National Institutes of Health grants AI053067, AI077613, AI101472, AI05135, and AI114511.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/9/9
Y1 - 2015/9/9
N2 - The mammalian gastrointestinal (GI) microbiota is highly adapted to thrive in the GI environment and performs key functions related to host nutrition, physiology, development, immunity, and behavior. Successful host-bacterial associations require chemical signaling and optimal nutrient utilization and exchange. However, this important balance can be severely disrupted by environmental stimuli, with one of the most common insults upon the microbiota being infectious diseases. Although the microbiota acts as a barrier toward enteric pathogens, many enteric pathogens exploit signals and nutrients derived from both the microbiota and host to regulate their virulence programs. Here we review several signaling and nutrient recognition systems employed by GI pathogens to regulate growth and virulence. We discuss how shifts in the microbiota composition change host susceptibility to infection and how dietary changes or manipulation of the microbiota could potentially prevent and/or ameliorate GI infections.
AB - The mammalian gastrointestinal (GI) microbiota is highly adapted to thrive in the GI environment and performs key functions related to host nutrition, physiology, development, immunity, and behavior. Successful host-bacterial associations require chemical signaling and optimal nutrient utilization and exchange. However, this important balance can be severely disrupted by environmental stimuli, with one of the most common insults upon the microbiota being infectious diseases. Although the microbiota acts as a barrier toward enteric pathogens, many enteric pathogens exploit signals and nutrients derived from both the microbiota and host to regulate their virulence programs. Here we review several signaling and nutrient recognition systems employed by GI pathogens to regulate growth and virulence. We discuss how shifts in the microbiota composition change host susceptibility to infection and how dietary changes or manipulation of the microbiota could potentially prevent and/or ameliorate GI infections.
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U2 - 10.1016/j.chom.2015.08.007
DO - 10.1016/j.chom.2015.08.007
M3 - Review article
C2 - 26355214
AN - SCOPUS:84941284307
SN - 1931-3128
VL - 18
SP - 275
EP - 284
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 3
ER -