Fractionated total body irradiation for metastatic neuroblastoma

Larry E. Kun, James T. Casper, Robert W. Kline, Victoria D. Piaskowski

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Twelve patients over one year old with neuroblastoma (NBL) metastatic to bone and bone marrow entered a study of adjuvant low-dose, fractionated total body irradiation (TBI). Six children who achieved a "complete clinical response" following chemotherapy (cyclophosphamide and adriamycin) and surgical resection of the abdominal primary received TBI (10 rad/fraction to totals of 100-120 rad/10-12 fx/12-25 days). Two children received concurrent local irradiation for residual abdominal tumor. The intervals from cessation of chemotherapy to documented progression ranged from 2-16 months, not substantially different from patients receiving similar chemotherapy and surgery without TBI. Three additional children with progressive NBL received similar TBI (80-120 rad/8-12 fx) without objective response.

Original languageEnglish (US)
Pages (from-to)1599-1602
Number of pages4
JournalInternational journal of radiation oncology, biology, physics
Issue number11
StatePublished - Nov 1981


  • Neuroblastoma
  • Total body irradiation

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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