Fluorescence molecular imaging: Microscopic to macroscopic

Sachin V. Patwardhan, Walter J. Akers, Sharon Bloch

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Medical imaging has revolutionized our understanding and ability to monitor specific macroscopic physical, physiological, and metabolic functions at cellular and subcellular levels. In the years to come, it will enable detection and characterization of disease even before anatomic changes become apparent. Fluorescence molecular imaging is revolutionarizing drug discovery and development with real-time in vivo monitoring in intact tissues. Technological advancements have taken fluorescence based imaging from microscopy to preclinical and clinical instruments for medical imaging. This chapter describes the current state of technology associated with in vivo noninvasive or minimally invasive fluorescence imaging along with the underlying principles. An overview of microscopic and macroscopic fluorescence imaging techniques is presented and their role in the development and applications of exogenous fluorescence contrast agents is discussed.

Original languageEnglish (US)
Title of host publicationPrinciples and Advanced Methods in Medical Imaging and Image Analysis
PublisherWorld Scientific Publishing Co.
Number of pages26
ISBN (Electronic)9789812814807
ISBN (Print)9789812705341
StatePublished - Jan 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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