Flow-independent 3D whole-heart vessel wall imaging using an interleaved T2-preparation acquisition

Marcelo E. Andia, Markus Henningsson, Tarique Hussain, Alkystis Phinikaridou, Andrea Protti, Gerald Greil, Rene M. Botnar

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Current techniques to visualize the arterial vessel wall are limited in coverage because most of them are flow dependent. In this study, we present a novel technique for flow-independent vessel wall imaging that takes advantage of the differences in T2 relaxation time of arterial blood and surrounding tissues using the T2-preparation prepulse. The technique is based on the acquisition and subtraction of two data sets, one obtained with and one without T2-preparation prepulse. This approach allows for nulling the signal of arterial blood while maintaining signal from muscle and vessel wall. The result of the subtraction is a flow-independent black-blood vessel wall image. To minimize the motion sensitivity of the subtraction step, we developed an interleaved acquisition for the T2-preparation prepulse and non-T2-preparation prepulse images, which allows obtaining coronary vessel wall images from a whole-heart acquisition with minimal misregistration artefacts. In this article, we present the technique and preliminary results in healthy subjects. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)150-157
Number of pages8
JournalMagnetic resonance in medicine
Issue number1
StatePublished - Jan 2013


  • T2-preparation
  • atherosclerosis
  • black blood
  • vessel wall

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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