Flourine-19 NMR spectroscopy and imaging investigations of myocardial perfusion and cardiac function

Ray L. Nunnally; Evelyn E Babcock; Sherye D. Horner; Ronald M Peshock

doi:10.1016/0730-725X(85)90404-7

Flourine-19 NMR spectroscopy and imaging investigations of myocardial perfusion and cardiac function

Ray L. Nunnally, Evelyn E Babcock, Sherye D. Horner, Ronald M Peshock

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Fluorine-19 nuclear magnetic resonance images of rabbit hearts have been obtained with the administration of a fluorinated contrast compound. The use of fluorine-labeled compounds allows differences in tissue perfusion to be demonstrated between hearts with and without coronary artery ligation. In postischemic reperfusion studies, regional hypoperfusion is also demonstrated by ¹⁹F imaging. The results of in vivo rabbit studies show that ¹⁹F NMR can be used to monitor the rate of blood pool and extravascular space dilution of a single bolus injection of either a water soluble or emulsified fluorine-labeled agent.

Original language	English (US)
Pages (from-to)	399-405
Number of pages	7
Journal	Magnetic Resonance Imaging
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/0730-725X(85)90404-7
State	Published - 1985

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1016/0730-725X(85)90404-7

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title = "Flourine-19 NMR spectroscopy and imaging investigations of myocardial perfusion and cardiac function",

abstract = "Fluorine-19 nuclear magnetic resonance images of rabbit hearts have been obtained with the administration of a fluorinated contrast compound. The use of fluorine-labeled compounds allows differences in tissue perfusion to be demonstrated between hearts with and without coronary artery ligation. In postischemic reperfusion studies, regional hypoperfusion is also demonstrated by 19F imaging. The results of in vivo rabbit studies show that 19F NMR can be used to monitor the rate of blood pool and extravascular space dilution of a single bolus injection of either a water soluble or emulsified fluorine-labeled agent.",

author = "Nunnally, {Ray L.} and Babcock, {Evelyn E} and Horner, {Sherye D.} and Peshock, {Ronald M}",

note = "Funding Information: Research Service Award #5F32 HL06971-02 (EEB), Mal-linckrodt, Inc. (RLN, RMP), and The Moss Heart Foundation (RLN). We wish to acknowledge the excellent technical assistance of Paula B. Walker, Karen Nguyen, Charles J. Storey, Paul Anderson, and Bradley G. Culter. Funding Information: Acknowledgments-This work was supported in part by grants from the American Heart Association #81-950 (RLN), NIH Clinical Investigator Award #I-KOS-HLOI 157 (RMP), NIH #5ROl-HL27472-03 (RLN), National",

year = "1985",

doi = "10.1016/0730-725X(85)90404-7",

language = "English (US)",

volume = "3",

pages = "399--405",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier Inc.",

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T1 - Flourine-19 NMR spectroscopy and imaging investigations of myocardial perfusion and cardiac function

AU - Nunnally, Ray L.

AU - Babcock, Evelyn E

AU - Horner, Sherye D.

AU - Peshock, Ronald M

N1 - Funding Information: Research Service Award #5F32 HL06971-02 (EEB), Mal-linckrodt, Inc. (RLN, RMP), and The Moss Heart Foundation (RLN). We wish to acknowledge the excellent technical assistance of Paula B. Walker, Karen Nguyen, Charles J. Storey, Paul Anderson, and Bradley G. Culter. Funding Information: Acknowledgments-This work was supported in part by grants from the American Heart Association #81-950 (RLN), NIH Clinical Investigator Award #I-KOS-HLOI 157 (RMP), NIH #5ROl-HL27472-03 (RLN), National

PY - 1985

Y1 - 1985

N2 - Fluorine-19 nuclear magnetic resonance images of rabbit hearts have been obtained with the administration of a fluorinated contrast compound. The use of fluorine-labeled compounds allows differences in tissue perfusion to be demonstrated between hearts with and without coronary artery ligation. In postischemic reperfusion studies, regional hypoperfusion is also demonstrated by 19F imaging. The results of in vivo rabbit studies show that 19F NMR can be used to monitor the rate of blood pool and extravascular space dilution of a single bolus injection of either a water soluble or emulsified fluorine-labeled agent.

AB - Fluorine-19 nuclear magnetic resonance images of rabbit hearts have been obtained with the administration of a fluorinated contrast compound. The use of fluorine-labeled compounds allows differences in tissue perfusion to be demonstrated between hearts with and without coronary artery ligation. In postischemic reperfusion studies, regional hypoperfusion is also demonstrated by 19F imaging. The results of in vivo rabbit studies show that 19F NMR can be used to monitor the rate of blood pool and extravascular space dilution of a single bolus injection of either a water soluble or emulsified fluorine-labeled agent.

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IS - 4

ER -

Flourine-19 NMR spectroscopy and imaging investigations of myocardial perfusion and cardiac function

Abstract

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