Flipping MLL1's switch one proline at a time

Edward J. Grow; Joanna Wysocka

doi:10.1016/j.cell.2010.06.013

Flipping MLL1's switch one proline at a time

Edward J. Grow, Joanna Wysocka

Research output: Contribution to journal › Short survey › peer-review

12 Scopus citations

Abstract

The MLL1 (mixed lineage leukemia 1) protein, which is often disrupted in leukemia, both activates and represses Hox genes during hematopoiesis. Now, Wang et al. (2010) demonstrate that the cyclophilin CyP33 underpins this regulatory switch by altering the state of MLL1 through cis-trans proline isomerization in the linker region between MLL1's third PHD finger and bromodomain.

Original language	English (US)
Pages (from-to)	1108-1110
Number of pages	3
Journal	Cell
Volume	141
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2010.06.013
State	Published - Jun 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2010.06.013

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title = "Flipping MLL1's switch one proline at a time",

abstract = "The MLL1 (mixed lineage leukemia 1) protein, which is often disrupted in leukemia, both activates and represses Hox genes during hematopoiesis. Now, Wang et al. (2010) demonstrate that the cyclophilin CyP33 underpins this regulatory switch by altering the state of MLL1 through cis-trans proline isomerization in the linker region between MLL1's third PHD finger and bromodomain.",

author = "Grow, {Edward J.} and Joanna Wysocka",

year = "2010",

month = jun,

doi = "10.1016/j.cell.2010.06.013",

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volume = "141",

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journal = "Cell",

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T1 - Flipping MLL1's switch one proline at a time

AU - Grow, Edward J.

AU - Wysocka, Joanna

PY - 2010/6

Y1 - 2010/6

N2 - The MLL1 (mixed lineage leukemia 1) protein, which is often disrupted in leukemia, both activates and represses Hox genes during hematopoiesis. Now, Wang et al. (2010) demonstrate that the cyclophilin CyP33 underpins this regulatory switch by altering the state of MLL1 through cis-trans proline isomerization in the linker region between MLL1's third PHD finger and bromodomain.

AB - The MLL1 (mixed lineage leukemia 1) protein, which is often disrupted in leukemia, both activates and represses Hox genes during hematopoiesis. Now, Wang et al. (2010) demonstrate that the cyclophilin CyP33 underpins this regulatory switch by altering the state of MLL1 through cis-trans proline isomerization in the linker region between MLL1's third PHD finger and bromodomain.

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U2 - 10.1016/j.cell.2010.06.013

DO - 10.1016/j.cell.2010.06.013

M3 - Short survey

C2 - 20602992

AN - SCOPUS:77953909750

SN - 0092-8674

VL - 141

SP - 1108

EP - 1110

JO - Cell

JF - Cell

IS - 7

ER -

Flipping MLL1's switch one proline at a time

Abstract

ASJC Scopus subject areas

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