Flipping MLL1's switch one proline at a time

Edward J. Grow, Joanna Wysocka

Research output: Contribution to journalShort surveypeer-review

12 Scopus citations


The MLL1 (mixed lineage leukemia 1) protein, which is often disrupted in leukemia, both activates and represses Hox genes during hematopoiesis. Now, Wang et al. (2010) demonstrate that the cyclophilin CyP33 underpins this regulatory switch by altering the state of MLL1 through cis-trans proline isomerization in the linker region between MLL1's third PHD finger and bromodomain.

Original languageEnglish (US)
Pages (from-to)1108-1110
Number of pages3
Issue number7
StatePublished - Jun 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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