Finding new clock components: Past and future

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations


The molecular mechanism of circadian clocks has been unraveled primarily by the use of phenotype-driven (forward) genetic analysis in a number of model systems. We are now in a position to consider what constitutes a clock component, whether we can establish criteria for clock components, and whether we have found most of the primary clock components. This perspective discusses clock genes and how genetics, molecular biology, and biochemistry have been used to find clock genes in the past and how they will be used in the future.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalJournal of Biological Rhythms
Issue number5
StatePublished - Oct 2004


  • Circadian clock components
  • Clock genes
  • Forward genetics
  • Phenotype

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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