TY - JOUR
T1 - Fifth Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report
AU - Pedimacs Investigators
AU - Rossano, Joseph W.
AU - VanderPluym, Christina J.
AU - Peng, David M.
AU - Hollander, Seth A.
AU - Maeda, Katsuhide
AU - Adachi, Iki
AU - Davies, Ryan R.
AU - Simpson, Kathleen E.
AU - Fynn-Thompson, Francis
AU - Conway, Jennifer
AU - Law, Sabrina P.
AU - Cantor, Ryan S.
AU - Koehl, Devin
AU - Jacobs, Jeffrey P.
AU - Amdani, Shahnawaz
AU - Kirklin, James K.
AU - Morales, David L.S.
N1 - Publisher Copyright:
© 2021 The Society of Thoracic Surgeons
PY - 2021/12
Y1 - 2021/12
N2 - Background: The Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) provides detailed information on pediatric patients supported with ventricular assist devices (VADs). Methods: From September 19, 2012, to December 31, 2020, 1229 devices in 1011 patients were reported to the registry from 47 North American Hospitals in patients aged younger than 19 years. Results: Cardiomyopathy was the most common underlying etiology (58%), followed by congenital heart disease (CHD; 25%) and myocarditis (10%). The most common devices implanted were implantable continuous (IC; 419 [41%]), followed by paracorporeal pulsatile (PP; 269 [27%]), paracorporeal continuous (PC; 263 [26%]), and percutaneous (53 [5%]). Overall, at 6 months after VAD implantation, 83% had a positive outcome (transplant, explant, or alive on device). The freedom from stroke at 3 months was highest in IC VADs (93%), compared with PP VADs (84%) and with PC VADs (75%). There were differences in survival by device type, with patients on IC VADs having the best overall survival and those on PC having the lowest overall survival, though the patient populations being supported by each VAD type differed significantly from each other. Conclusions: This Fifth Pedimacs Report demonstrates the continued robust growth of VADs in the pediatric community, now with more than 1000 patients reported to the registry. The multiple available device types (PC, PP, IC) serve different populations with different pre-VAD risk profiles, which may account for differences in survival and adverse events between device types.
AB - Background: The Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) provides detailed information on pediatric patients supported with ventricular assist devices (VADs). Methods: From September 19, 2012, to December 31, 2020, 1229 devices in 1011 patients were reported to the registry from 47 North American Hospitals in patients aged younger than 19 years. Results: Cardiomyopathy was the most common underlying etiology (58%), followed by congenital heart disease (CHD; 25%) and myocarditis (10%). The most common devices implanted were implantable continuous (IC; 419 [41%]), followed by paracorporeal pulsatile (PP; 269 [27%]), paracorporeal continuous (PC; 263 [26%]), and percutaneous (53 [5%]). Overall, at 6 months after VAD implantation, 83% had a positive outcome (transplant, explant, or alive on device). The freedom from stroke at 3 months was highest in IC VADs (93%), compared with PP VADs (84%) and with PC VADs (75%). There were differences in survival by device type, with patients on IC VADs having the best overall survival and those on PC having the lowest overall survival, though the patient populations being supported by each VAD type differed significantly from each other. Conclusions: This Fifth Pedimacs Report demonstrates the continued robust growth of VADs in the pediatric community, now with more than 1000 patients reported to the registry. The multiple available device types (PC, PP, IC) serve different populations with different pre-VAD risk profiles, which may account for differences in survival and adverse events between device types.
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U2 - 10.1016/j.athoracsur.2021.10.001
DO - 10.1016/j.athoracsur.2021.10.001
M3 - Article
C2 - 34648810
AN - SCOPUS:85117905080
SN - 0003-4975
VL - 112
SP - 1763
EP - 1774
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 6
ER -