Fertilization: Conventional IVF versus ICSI

Research output: Chapter in Book/Report/Conference proceedingChapter


Intracytoplasmic sperm injection (ICSI) was developed in humans in the early 1990s as a mechanism to overcome complete fertilization failure due to severe male factor infertility. ICSI can be used with motile, nonmotile, ejaculated, or surgically retrieved testicular sperm to produce a viable embryo resulting in live birth. As the safety and efficacy of ICSI were demonstrated, its use became more widespread. ICSI has been applied to other infertility-related issues such as unexplained infertility, use with frozen gametes, serodiscordant couples, and patients with diminished ovarian reserve and/or advanced reproductive age, in addition to male factor infertility. While, in general, ICSI use may not show a major disadvantage over conventional insemination, the insemination method should be a carefully considered option based on individual patient needs.

Original languageEnglish (US)
Title of host publicationDiminished Ovarian Reserve and Assisted Reproductive Technologies
Subtitle of host publicationCurrent Research and Clinical Management
PublisherSpringer International Publishing
Number of pages10
ISBN (Electronic)9783030232351
ISBN (Print)9783030232344
StatePublished - Jan 1 2019


  • ICSI
  • In vitro fertilization
  • Intracytoplasmic sperm injection

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)


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