Abstract
Intracytoplasmic sperm injection (ICSI) was developed in humans in the early 1990s as a mechanism to overcome complete fertilization failure due to severe male factor infertility. ICSI can be used with motile, nonmotile, ejaculated, or surgically retrieved testicular sperm to produce a viable embryo resulting in live birth. As the safety and efficacy of ICSI were demonstrated, its use became more widespread. ICSI has been applied to other infertility-related issues such as unexplained infertility, use with frozen gametes, serodiscordant couples, and patients with diminished ovarian reserve and/or advanced reproductive age, in addition to male factor infertility. While, in general, ICSI use may not show a major disadvantage over conventional insemination, the insemination method should be a carefully considered option based on individual patient needs.
Original language | English (US) |
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Title of host publication | Diminished Ovarian Reserve and Assisted Reproductive Technologies |
Subtitle of host publication | Current Research and Clinical Management |
Publisher | Springer International Publishing |
Pages | 221-230 |
Number of pages | 10 |
ISBN (Electronic) | 9783030232351 |
ISBN (Print) | 9783030232344 |
DOIs | |
State | Published - Jan 1 2019 |
Keywords
- ICSI
- In vitro fertilization
- Intracytoplasmic sperm injection
ASJC Scopus subject areas
- Health Professions(all)
- Medicine(all)