Abstract
Oxidative stress induced by an imbalance between oxidant and antioxidant factors is linked to various types of regulated cell death, which affects many aspects of tumor biology. Ferroptosis is a form of reactive oxygen species-dependent cell death, which is characterized by iron accumulation and lipid peroxidation. Although the direct molecular effector for ferroptosis is not known, ACSL4-and lipoxygenase-mediated production of lipid peroxides play a major role in the induction of ferroptosis. Autophagy, including ferritinophagy, lipophagy, clockophagy, and chaperone-mediated autophagy, contributes to ferroptotic cancer cell death through the upregulation of oxidative injury. In contrast, there are many antioxidant systems or proteins, such as the cystine/glutamate antiporter system xc -, GPX4, and NFE2L2, in place to limit reactive oxygen species-induced ferroptotic cancer cell death. Understanding the types of ferroptosis and their molecular machinery could open new approaches to cancer therapy.
Original language | English (US) |
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Title of host publication | Cancer |
Subtitle of host publication | Oxidative Stress and Dietary Antioxidants |
Publisher | Elsevier |
Pages | 149-158 |
Number of pages | 10 |
ISBN (Electronic) | 9780128195475 |
DOIs | |
State | Published - Jan 1 2021 |
Keywords
- ACSL4
- Autophagy
- Cancer
- Ferroptosis
- GPX4
- Iron
- Lipid peroxidation
- Lipoxygenase
- NFE2L2
- TP53
ASJC Scopus subject areas
- General Medicine