FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence

Donita R. Croft, John Trapp, Kemp Kernstine, Peter Kirchner, Brian Mullan, Jeffery Galvin, Michael W. Peterson, Thomas Gross, Geoffrey McLennan, Jeffrey A. Kern

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


Study objective: Determine the sensitivity and specificity of [F-18]-fluorine-2-deoxy-D-glucose positron emission tomography (FDG-PET) in differentiating non-small cell lung cancer (NSCLC) from benign solitary pulmonary nodules (SPNs) in a region with a high endemic rate of histoplamosis. Design: Prospective, clinical study. Setting: University, tertiary referral hospital in the upper Mississippi River valley. Patients: Ninety patients with SPNs. Interventions: Independent interpretation of FDG-PET imaging, computed tomography and pathologic evaluation of the SPNs. Measurements and results: To detect malignant SPNs, FDG-PET imaging had a sensitivity of 93%, a specificity of 40%, a positive predictive value (PPV) of 88% and a negative predictive value (NPV) of 55%. Conclusions: In a region with a high prevalence of pulmonary fungal infection, FDG-PET is sensitive but has a low specificity and NPV for identifying NSCLC.In our study cohort, FDG-PET does not appear to reduce the need for SPN biopsies.

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
JournalLung Cancer
Issue number3
StatePublished - 2002


  • Carcinoma non-small-cell lung
  • Computed tomography
  • Histoplasmosis
  • Infection, fungal
  • Lung neoplasms
  • Positron-emission tomography
  • Pulmonary nodule solitary

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research


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