Fast Dissolution Dynamic Nuclear Polarization NMR of 13C-Enriched 89Y-DOTA Complex: Experimental and Theoretical Considerations

Lloyd Lumata; Matthew Merritt; Craig Malloy; A. Dean Sherry; Zoltan Kovacs

doi:10.1007/s00723-012-0335-8

Fast Dissolution Dynamic Nuclear Polarization NMR of ¹³C-Enriched ⁸⁹Y-DOTA Complex: Experimental and Theoretical Considerations

Lloyd Lumata, Matthew Merritt, Craig Malloy, A. Dean Sherry, Zoltan Kovacs

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Abstract

The yttrium complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(1′- ¹³C-acetic acid) [ ¹³C]DOTA was synthesized. Fast dissolution dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) studies revealed that the ⁸⁹Y, ¹³C, and ¹⁵N nuclei present in the complex could be co-polarized at the same optimum microwave irradiation frequency. The liquid-state spin-lattice relaxation time T ₁ of these nuclei were found to be reasonably long to preserve some or most of the DNP-enhanced polarization after dissolution. The hyperpolarized ¹³C and ⁸⁹Y NMR signals were optimized in different glassing mixtures. The overall results are discussed in light of the thermal mixing model of DNP.

Original language	English (US)
Pages (from-to)	69-79
Number of pages	11
Journal	Applied Magnetic Resonance
Volume	43
Issue number	1-2
DOIs	https://doi.org/10.1007/s00723-012-0335-8
State	Published - Jul 2012

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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title = "Fast Dissolution Dynamic Nuclear Polarization NMR of 13C-Enriched 89Y-DOTA Complex: Experimental and Theoretical Considerations",

abstract = "The yttrium complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(1′- 13C-acetic acid) [ 13C]DOTA was synthesized. Fast dissolution dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) studies revealed that the 89Y, 13C, and 15N nuclei present in the complex could be co-polarized at the same optimum microwave irradiation frequency. The liquid-state spin-lattice relaxation time T 1 of these nuclei were found to be reasonably long to preserve some or most of the DNP-enhanced polarization after dissolution. The hyperpolarized 13C and 89Y NMR signals were optimized in different glassing mixtures. The overall results are discussed in light of the thermal mixing model of DNP.",

author = "Lloyd Lumata and Matthew Merritt and Craig Malloy and Sherry, {A. Dean} and Zoltan Kovacs",

note = "Funding Information: Acknowledgments We acknowledge the National Institutes of Health (grant no. R21EB009147) for the financial support on this work.",

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AU - Lumata, Lloyd

AU - Merritt, Matthew

AU - Malloy, Craig

AU - Sherry, A. Dean

AU - Kovacs, Zoltan

N1 - Funding Information: Acknowledgments We acknowledge the National Institutes of Health (grant no. R21EB009147) for the financial support on this work.

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N2 - The yttrium complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(1′- 13C-acetic acid) [ 13C]DOTA was synthesized. Fast dissolution dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) studies revealed that the 89Y, 13C, and 15N nuclei present in the complex could be co-polarized at the same optimum microwave irradiation frequency. The liquid-state spin-lattice relaxation time T 1 of these nuclei were found to be reasonably long to preserve some or most of the DNP-enhanced polarization after dissolution. The hyperpolarized 13C and 89Y NMR signals were optimized in different glassing mixtures. The overall results are discussed in light of the thermal mixing model of DNP.

AB - The yttrium complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(1′- 13C-acetic acid) [ 13C]DOTA was synthesized. Fast dissolution dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) studies revealed that the 89Y, 13C, and 15N nuclei present in the complex could be co-polarized at the same optimum microwave irradiation frequency. The liquid-state spin-lattice relaxation time T 1 of these nuclei were found to be reasonably long to preserve some or most of the DNP-enhanced polarization after dissolution. The hyperpolarized 13C and 89Y NMR signals were optimized in different glassing mixtures. The overall results are discussed in light of the thermal mixing model of DNP.

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Fast Dissolution Dynamic Nuclear Polarization NMR of ¹³C-Enriched ⁸⁹Y-DOTA Complex: Experimental and Theoretical Considerations

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