Abstract
Background:Studies of family history of cancer in paediatric germ cell tumours (GCTs) are few, and none has had sufficient sample size to specifically evaluate family history of GCT.Methods:We utilised family history data from a paediatric GCT study to calculate standardised incidence ratios (SIR) for GCT and other cancers using age- and sex-specific incidence rates from the SEER Program.Results:This analysis included 7998 relatives of paediatric GCT probands. We observed a higher number of GCT cases than expected in male and female relatives of probands (SIR=2.38, 95% CI 1.25, 3.51 for males; SIR=14.3, 95% CI 0.29, 28.4 for females). Further, we observed a particularly strong SIR for relatives of probands with intracranial GCT (SIR=8.07, 95% CI 3.51, 12.6). The SIR for relatives of probands with ovarian GCT was also elevated but did not reach statistical significance (SIR 4.35, 95% CI 0-9.27). Other notable associations include elevated SIRs for melanoma in male relatives and reduced SIRs for lymphatic/haematologic malignancies in male and female relatives.Conclusions:These results support the hypothesis that familial aggregation of GCT occurs in males and females.
Original language | English (US) |
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Pages (from-to) | 121-126 |
Number of pages | 6 |
Journal | British journal of cancer |
Volume | 118 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2018 |
Keywords
- epidemiology
- germ cell tumour
- intracranial
- ovary
- paediatric cancer
- testis
ASJC Scopus subject areas
- Oncology
- Cancer Research