Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

Pengyuan Liu, Haris G. Vikis, Daolong Wang, Yan Lu, Yian Wang, Ann G. Schwartz, Susan M. Pinney, Ping Yang, Mariza De Andrade, Gloria M. Petersen, Jonathan S. Wiest, Pamela R. Fain, Adi Gazdar, Colette Gaba, Henry Rothschild, Diptasri Mandal, Teresa Coons, Juwon Lee, Elena Kupert, Daniela SeminaraJohn Minna, Joan E. Bailey-Wilson, Xifeng Wu, Margaret R. Spitz, Timothy Eisen, Richard S. Houlston, Christopher I. Amos, Marshall W. Anderson, Ming You

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.

Original languageEnglish (US)
Pages (from-to)1326-1330
Number of pages5
JournalJournal of the National Cancer Institute
Issue number18
StatePublished - Sep 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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