Factors affecting the dose response to oxytocin for labor stimulation

A. J. Satin, K. J. Leveno, M. L. Sherman, D. D. McIntire

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


For nearly 40 years synthetic oxytocin has been used for labor stimulation by titrating dosage rate to uterine contractions. We used a computerized data base to determine variables affecting the dose response to oxytocin in 1773 pregnancies. Statistically important predictors of required oxytocin dosage included cervical dilatation, parity, and gestational age. Maternal body surface area was found to be associated with a higher oxytocin dosage in women undergoing induction of labor. However, the broad range of the statistical confidence intervals precluded prediction of a given pregnancy's oxytocin requirement.

Original languageEnglish (US)
Pages (from-to)1260-1261
Number of pages2
JournalAmerican journal of obstetrics and gynecology
Issue number4
StatePublished - Jan 1 1992


  • Oxytocin
  • labor augmentation
  • labor induction

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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