TY - JOUR
T1 - Factor structure and dimensionality of the two depression scales in STAR*D using level 1 datasets
AU - Bech, P.
AU - Fava, M.
AU - Trivedi, M. H.
AU - Wisniewski, S. R.
AU - Rush, A. J.
N1 - Funding Information:
Dr. Trivedi reports that he has received research support from the Agency for Healthcare Research and Quality (AHRQ), Corcept Therapeutics, Inc., Cyberonics, Inc., Merck, National Alliance for Research in Schizophrenia and Depression, National Institute of Mental Health, National Institute on Drug Abuse, Novartis, Pharmacia & Upjohn, Predix Pharmaceuticals (Epix), Solvay Pharmaceuticals, Inc., and Targacept. He has received consulting and speaker fees from Abbott Laboratories, Inc., Abdi Ibrahim, Akzo (Organon Pharmaceuticals Inc.), AstraZeneca, Bristol-Myers Squibb Company, Cephalon, Inc., Evotec, Fabre Kramer Pharmaceuticals, Inc., Forest Pharmaceuticals, GlaxoSmithKline, Janssen Pharmaceutica Products, LP, Johnson & Johnson PRD, Eli Lilly & Company, Meade Johnson, Medtronic, Neuronetics, Otsuka Pharmaceuticals, Parke-Davis Pharmaceuticals, Inc., Pfizer Inc., Sepracor, SHIRE Development, VantagePoint, and Wyeth-Ayerst Laboratories. Dr. Greer has received grant support from a National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award and National Institutes of Health.
PY - 2011/8
Y1 - 2011/8
N2 - Background: The factor structure and dimensionality of the HAM-D 17 and the IDS-C30 are as yet uncertain, because psychometric analyses of these scales have been performed without a clear separation between factor structure profile and dimensionality (total scores being a sufficient statistic). Methods: The first treatment step (Level 1) in the STAR*D study provided a dataset of 4041 outpatients with DSM-IV nonpsychotic major depression. The HAM-D17 and IDS-C30 were evaluated by principal component analysis (PCA) without rotation. Mokken analysis tested the unidimensionality of the IDS-C6, which corresponds to the unidimensional HAM-D6. Results: For both the HAM-D17 and IDS-C30, PCA identified a bi-directional factor contrasting the depressive symptoms versus the neurovegetative symptoms. The HAM-D6 and the corresponding IDS-C6 symptoms all emerged in the depression factor. Both the HAM-D6 and IDS-C 6 were found to be unidimensional scales, i.e., their total scores are each a sufficient statistic for the measurement of depressive states. Limitations: STAR*D used only one medication in Level 1. Conclusions: The unidimensional HAM-D6 and IDS-C6 should be used when evaluating the pure clinical effect of antidepressive treatment, whereas the multidimensional HAM-D17 and IDS-C30 should be considered when selecting antidepressant treatment.
AB - Background: The factor structure and dimensionality of the HAM-D 17 and the IDS-C30 are as yet uncertain, because psychometric analyses of these scales have been performed without a clear separation between factor structure profile and dimensionality (total scores being a sufficient statistic). Methods: The first treatment step (Level 1) in the STAR*D study provided a dataset of 4041 outpatients with DSM-IV nonpsychotic major depression. The HAM-D17 and IDS-C30 were evaluated by principal component analysis (PCA) without rotation. Mokken analysis tested the unidimensionality of the IDS-C6, which corresponds to the unidimensional HAM-D6. Results: For both the HAM-D17 and IDS-C30, PCA identified a bi-directional factor contrasting the depressive symptoms versus the neurovegetative symptoms. The HAM-D6 and the corresponding IDS-C6 symptoms all emerged in the depression factor. Both the HAM-D6 and IDS-C 6 were found to be unidimensional scales, i.e., their total scores are each a sufficient statistic for the measurement of depressive states. Limitations: STAR*D used only one medication in Level 1. Conclusions: The unidimensional HAM-D6 and IDS-C6 should be used when evaluating the pure clinical effect of antidepressive treatment, whereas the multidimensional HAM-D17 and IDS-C30 should be considered when selecting antidepressant treatment.
KW - Hamilton depression scale
KW - Inventory of Depressive Symptomatology
KW - Item response theory analysis
KW - Principal component analysis
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U2 - 10.1016/j.jad.2011.03.011
DO - 10.1016/j.jad.2011.03.011
M3 - Article
C2 - 21440308
AN - SCOPUS:79960322438
SN - 0165-0327
VL - 132
SP - 396
EP - 400
JO - Journal of affective disorders
JF - Journal of affective disorders
IS - 3
ER -