Abstract
The role of aldosterone in regulating K+ excretion in the distal nephron is well established in kidney physiology. In addition to effects on the kidney, aldosterone modulates K+ and Na + transport in salivary fluid, sweat, airway epithelia, and colonic fluid. More controversial and less well defined is the role of aldosterone in determining the internal distribution of K+ across cell membranes in nontransporting epithelia. In vivo studies have been limited by the difficulty in accurately measuring overall K+ balance and factoring in both variability and secondary changes in acid-base balance, systemic hemodynamics, and other K+ -regulatory factors such as hormones and adrenergic activity. Despite these limitations, the aggregate data support a contributory role of aldosterone along with insulin and catecholamines in the normal physiologic regulation of internal K+ distribution. The authors speculate differences in tissue sensitivity to aldosterone may also contribute to differential tissue response of cardiac and skeletal muscle to conditions of total body K+ depletion.
Original language | English (US) |
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Pages (from-to) | 561-568 |
Number of pages | 8 |
Journal | Kidney360 |
Volume | 3 |
Issue number | 3 |
DOIs | |
State | Published - Mar 31 2022 |
Keywords
- acid/base and electrolyte disorders
- aldosterone
- catecholamines
- extrarenal K homeostasis
- hyperkalemia
- hypokalemia
- insulin
- internal K distribution
- potassium
- potassium homeostasis
ASJC Scopus subject areas
- Nephrology
- Medicine (miscellaneous)