Extracellular Volume Overload and Increased Vasoconstriction in Patients with Recurrent Intradialytic Hypertension

Peter Noel Van Buren, Yunyun Zhou, Javier A. Neyra, Guanghua Xiao, Wanpen Vongpatanasin, Jula Inrig, Robert Toto

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background/Aims: Intradialytic hypertension (IH) occurs frequently in some hemodialysis patients and increases mortality risk. We simultaneously compared pre-dialysis, post-dialysis and changes in extracellular volume and hemodynamics in recurrent IH patients and controls. Methods: We performed a case-control study among prevalent hemodialysis patients with recurrent IH and hypertensive hemodialysis controls. We used bioimpedance spectroscopy and impedance cardiography to compare pre-dialysis, post-dialysis, and intradialytic change in total body water (TBW) and extracellular water (ECW), as well as cardiac index (CI) and total peripheral resistance index (TPRI). Results: The ECW/TBW was 0.453 (0.05) pre-dialysis and 0.427 (0.04) post-dialysis in controls vs. 0.478 (0.03) and 0.461 (0.03) in IH patients (p=0.01 post-dialysis). The ECW/TBW change was -0.027 (0.03) in controls and -0.013 (0.02) in IH patients (p=0.1). In controls, pre- and post-dialysis TPRI were 3254 (994) and 2469 (529) dynes/sec/cm2/m2 vs. 2983 (747) and 3408 (980) dynes/sec/cm2/m2 in IH patients (p=0.002 post-dialysis). There were between-group differences in TPRI change (0=0.0001), but not CI (p=0.09). Conclusions: Recurrent intradialytic hypertension is associated with higher post-dialysis extracellular volume and TPRI. Intradialytic TPRI surges account for the vasoconstrictive state post-dialysis, but intradialytic fluid shifts may contribute to post-hemodialysis volume expansion.

Original languageEnglish (US)
Pages (from-to)802-814
Number of pages13
JournalKidney and Blood Pressure Research
Issue number6
StatePublished - Dec 1 2016


  • Bioimpedance Spectroscopy
  • Endothelin-1
  • Extracellular Volume
  • Hemodialysis
  • Intradialytic Hypertension
  • Peripheral Resistance

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine


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