Extracellular Regulation of Cell-to-Matrix Adhesion

P. A. Janmey, C. A. McCulloch, R. T. Miller

Research output: Chapter in Book/Report/Conference proceedingChapter


Cell adhesion to extracellular matrices involves specific bonds between cell membrane proteins and their extracellular ligands, less-defined interactions between macromolecules extending from the cell and matrix, and features of the matrix such as distribution of adhesion ligands, surface topography, electrostatic charge, and mechanical compliance. Many aspects of the cell phenotype are altered by changes in the matrix produced by other cells or environmental factors. This article summarizes how cell adhesion is altered by changes in the chemical or physical properties of the matrix and illustrates how matrix-dependent effects on cell function are associated with normal development or pathology.

Original languageEnglish (US)
Title of host publicationFunctional Cell Biology
PublisherElsevier Inc.
Number of pages7
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
StatePublished - Jan 1 2016


  • Collagen
  • Compliance
  • Connective tissue
  • Electrostatic
  • Fibronectin
  • Glycocalyx
  • Integrin
  • Membrane
  • Platelet
  • Repulsive interaction
  • Transmembrane

ASJC Scopus subject areas

  • Medicine(all)


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