TY - JOUR
T1 - Exploring the Possibility of Unique Molecular, Biological, and Tissue Effects With Hypofractionated Radiotherapy
AU - Story, Michael
AU - Kodym, Reinhard
AU - Saha, Debabrata
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/10
Y1 - 2008/10
N2 - High-dose hypofractionated radiotherapy is feasible because of technological advances that allow for the precise delivery of radiation to a target volume that contains a limited amount of normal tissue. No longer constrained by the normal tissue response of large fields, very large doses of radiation can be delivered. However, with the application of high doses of radiation to very precise treatment volumes, we find ourselves wondering if the fundamental principles that govern conventional radiotherapy apply. The conventions of tumor hypoxia, reoxygenation, tumor repopulation, and intrinsic radiosensitivity are all likely to be unique or play new roles in tumor or normal tissue response. With that in mind, we highlight several facets of tumor or normal tissue response in which a better understanding of tumor biology and radiation biology could be beneficial to the application of high dose per fraction treatment modalities or in which caution should be exercised.
AB - High-dose hypofractionated radiotherapy is feasible because of technological advances that allow for the precise delivery of radiation to a target volume that contains a limited amount of normal tissue. No longer constrained by the normal tissue response of large fields, very large doses of radiation can be delivered. However, with the application of high doses of radiation to very precise treatment volumes, we find ourselves wondering if the fundamental principles that govern conventional radiotherapy apply. The conventions of tumor hypoxia, reoxygenation, tumor repopulation, and intrinsic radiosensitivity are all likely to be unique or play new roles in tumor or normal tissue response. With that in mind, we highlight several facets of tumor or normal tissue response in which a better understanding of tumor biology and radiation biology could be beneficial to the application of high dose per fraction treatment modalities or in which caution should be exercised.
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U2 - 10.1016/j.semradonc.2008.04.006
DO - 10.1016/j.semradonc.2008.04.006
M3 - Article
C2 - 18725111
AN - SCOPUS:49749112884
SN - 1053-4296
VL - 18
SP - 244
EP - 248
JO - Seminars in Radiation Oncology
JF - Seminars in Radiation Oncology
IS - 4
ER -