Exploring Biomarkers of Phosphoinositide 3-Kinase Pathway Activation in the Treatment of Hormone Receptor Positive, Human Epidermal Growth Receptor 2 Negative Advanced Breast Cancer

Medicine & Life Sciences

• Phosphatidylinositol 3-Kinase 100%
• Phosphoinositide-3 Kinase Inhibitors 77%
• Hormones 69%
• Biomarkers 64%
• Breast Neoplasms 62%
• Growth 49%
• Protein Isoforms 44%
• 2-(3-(2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo(f)imidazo(1,2-d)(1,4)oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide 23%
• Alpelisib 20%
• NVP-BKM120 19%
• Mutation 18%
• Therapeutics 16%
• Liquid Biopsy 15%
• Aromatase Inhibitors 13%
• Therapeutic Index 13%
• Safety 12%
• Catalytic Domain 9%
• Clinical Trials 7%
• Neoplasms 7%
• Costs and Cost Analysis 6%
• Biopsy 6%