Abstract
Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-κB.
Original language | English (US) |
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Pages (from-to) | 6-21 |
Number of pages | 16 |
Journal | Cell Research |
Volume | 21 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2011 |
Keywords
- IKK
- NF-κB
- TAK1
- TRAFs
- ubiquitin
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology