Expanding role of ubiquitination in NF-κB signaling

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181 Scopus citations


Best known for its role in targeting protein degradation by the proteasome, ubiquitin modification has also emerged as an important mechanism that regulates cell signaling through proteasome-independent mechanisms. The role of ubiquitin as a versatile signaling tag is characteristically illustrated in the NF-κB pathways, which regulate a variety of physiological and pathological processes in response to diverse stimuli. Here, we review the role of ubiquitination in different steps of the NF-κB signaling cascades, focusing on recent advances in understanding the mechanisms of protein kinase activation by polyubiquitin chains in different pathways that converge on NF-κB.

Original languageEnglish (US)
Pages (from-to)6-21
Number of pages16
JournalCell Research
Issue number1
StatePublished - Jan 2011


  • IKK
  • NF-κB
  • TAK1
  • TRAFs
  • ubiquitin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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