Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease

Mustafa Işin; Ege Uysaler; Emre Özgür; Hikmet Köseoğlu; Öner Şanli; Ömer B. Yücel; Uğur Gezer; Nejat Dalay

doi:10.3389/fgene.2015.00168

Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease

Mustafa Işin, Ege Uysaler, Emre Özgür, Hikmet Köseoğlu, Öner Şanli, Ömer B. Yücel, Uğur Gezer, Nejat Dalay

Research output: Contribution to journal › Article › peer-review

186 Scopus citations

Abstract

Exosomes are membranous vesicles containing various biomolecules including lncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 lncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of lncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa.

Original language	English (US)
Article number	168
Journal	Frontiers in Genetics
Volume	6
Issue number	MAY
DOIs	https://doi.org/10.3389/fgene.2015.00168
State	Published - 2015

Keywords

Benign prostatic hyperplasia
Exosome
LncRNA
Non-invasive diagnosis
Prostate cancer

ASJC Scopus subject areas

Molecular Medicine
Genetics
Genetics(clinical)

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10.3389/fgene.2015.00168

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title = "Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease",

abstract = "Exosomes are membranous vesicles containing various biomolecules including lncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 lncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of lncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa.",

keywords = "Benign prostatic hyperplasia, Exosome, LncRNA, Non-invasive diagnosis, Prostate cancer",

author = "Mustafa I{\c s}in and Ege Uysaler and Emre {\"O}zg{\"u}r and Hikmet K{\"o}seoğlu and {\"O}ner {\c S}anli and Y{\"u}cel, {{\"O}mer B.} and Uğur Gezer and Nejat Dalay",

note = "Publisher Copyright: {\textcopyright} 2015 Isin, Uysaler, {\"o}zg{\"u}r, K{\"o}seoglu, Sanli, Y{\"u}cel, Gezer and Dalay.",

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AU - Işin, Mustafa

AU - Uysaler, Ege

AU - Özgür, Emre

AU - Köseoğlu, Hikmet

AU - Şanli, Öner

AU - Yücel, Ömer B.

AU - Gezer, Uğur

AU - Dalay, Nejat

PY - 2015

Y1 - 2015

N2 - Exosomes are membranous vesicles containing various biomolecules including lncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 lncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of lncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa.

AB - Exosomes are membranous vesicles containing various biomolecules including lncRNAs which are involved in cellular communication and are secreted from many cells including cancer cells. In our study, investigated the exosomal GAS5 and lincRNA-p21 lncRNA levels in urine samples from 30 patients with prostate cancer (PCa) and 49 patients with benign prostatic hyperplasia. Quantification of lncRNA molecules was performed by real-time PCR. We observed a significant difference in the exosomal lincRNA-p21 levels between PCa and BPH patients whereas the GAS5 levels did not reveal a difference. Our data suggest that the discriminative potential of exosomal lincRNA-p21 levels may help to improve the diagnostic prediction of the malignant state for patients with PCa.

KW - Benign prostatic hyperplasia

KW - Exosome

KW - LncRNA

KW - Non-invasive diagnosis

KW - Prostate cancer

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Exosomal lncRNA-p21 levels may help to distinguish prostate cancer from benign disease

Abstract

Keywords

ASJC Scopus subject areas

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