Evolution of protein structures and functions

Lisa N. Kinch, Nick V. Grishin

Research output: Contribution to journalReview articlepeer-review

133 Scopus citations


Within the ever-expanding repertoire of known protein sequences and structures, many examples of evolving three-dimensional structures are emerging that illustrate the plasticity and robustness of protein folds. The mechanisms by which protein folds change often include the fusion of duplicated domains, followed by divergence through mutation. Such changes reflect both the stability of protein folds and the requirements of protein function.

Original languageEnglish (US)
Pages (from-to)400-408
Number of pages9
JournalCurrent Opinion in Structural Biology
Issue number3
StatePublished - Jun 1 2002

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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