@article{f9e1094fd62a435c9d0a618d384cb238,
title = "Evidence for hormonal control of heart regenerative capacity during endothermy acquisition",
abstract = "Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative potential correlates with cardiomyocyte cell-cycle arrest and polyploidization as well as the development of postnatal endothermy. We reveal that diploid cardiomyocyte abundance across 41 species conforms to Kleiber's law-the 3/4-power law scaling of metabolism with bodyweight-and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level. Inactivation of thyroid hormone signaling reduces mouse cardiomyocyte polyploidization, delays cell-cycle exit, and retains cardiac regenerative potential in adults. Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothermy.",
author = "Kentaro Hirose and Payumo, {Alexander Y.} and Stephen Cutie and Alison Hoang and Hao Zhang and Romain Guyot and Dominic Lunn and Bigley, {Rachel B.} and Hongyao Yu and Jiajia Wang and Megan Smith and Ellen Gillett and Muroy, {Sandra E.} and Tobias Schmid and Emily Wilson and Field, {Kenneth A.} and Reeder, {Dee Ann M.} and Malcom Maden and Yartsev, {Michael M.} and Wolfgang, {Michael J.} and Frank Gr{\"u}tzner and Scanlan, {Thomas S.} and Szweda, {Luke I.} and Rochelle Buffenstein and Guang Hu and Frederic Flamant and Olgin, {Jeffrey E.} and Huang, {Guo N.}",
note = "Funding Information: This work is supported by JSPS Overseas Research Fellowships (to K.H.), a UCSF-IRACDA postdoctoral fellowship (to A.P.), a NIGMS IMSD fellowship and Hillblom fellowship (to S.C.), an ARC fellowship (to F.G.), the Agence Nationale de Recherche Thyromut2 program, ANR-15-CE14-0011-01 (to F.F.), Intramural Research Program of the NIH, National Institute of Environmental Health Sciences 1ZIAES102745 (to G. H.), NIH (R01HL13845) Pathway to Independence Award (R00HL114738), Edward Mallinckrodt Jr. Foundation, March of Dimes Basil O'Conner Scholar Award, American Heart Association Beginning Grant-in-Aid, American Federation for Aging Research, Life Sciences Research Foundation, Program for Breakthrough Biomedical Research, UCSF Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Seed Grant, UCSF Academic Senate Committee on Research, REAC Award (Harris Fund), Department of Defense, and Cardiovascular Research Institute (to G.N.H.). Publisher Copyright: {\textcopyright} 2017 The Authors.",
year = "2019",
doi = "10.1126/science.aar2038",
language = "English (US)",
volume = "364",
pages = "184--188",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6436",
}