Evaluation of the HC-04 cell line as an in vitro model for mechanistic assessment of changes in hepatic cytochrome P450 3A during adenovirus infection

Chemical Compounds

• Pregnane 100%
• Androstane Receptor Agonist 79%
• 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime 77%
• Cytochrome P450 73%
• Pregnane X Receptor Agonist 72%
• Androstane 50%
• Ketoconazole 46%
• Rifampicin 46%
• Retinoid 44%
• Dexamethasone 43%
• Phenobarbital 43%
• Inducer 39%
• Lipopolysaccharide 37%
• Pharmacological Metabolism 26%
• Modification 18%
• Drug 17%
• Amount 14%

Medicine & Life Sciences

• Adenoviridae Infections 92%
• Cytochrome P-450 CYP3A 77%
• Pregnane X Receptor 49%
• Cell Line 40%
• Liver 35%
• constitutive androstane receptor 34%
• In Vitro Techniques 29%
• Viruses 22%
• Infections 21%
• Hepatocyte Nuclear Factor 4 18%
• Retinoid X Receptors 15%
• Ketoconazole 14%
• Peroxisome Proliferator-Activated Receptors 13%
• Phenobarbital 12%
• Rifampin 12%
• Adenoviridae 11%
• Toxicology 11%
• Dexamethasone 10%
• Lipopolysaccharides 9%
• Protein Isoforms 9%
• Virus Diseases 8%
• Pharmaceutical Preparations 4%