Evaluation of Cuff-Induced Ischemia in the Lower Extremity by Magnetic Resonance Oximetry

Michael C. Langham, Thomas F. Floyd, Emile R. Mohler, Jeremy F. Magland, Felix W. Wehrli

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Objectives: The aim of this study was to evaluate vascular function in the lower extremities by making direct time-course measurement of oxygen saturation in the femoral/popliteal arteries and veins during cuff-induced reactive hyperemia with magnetic resonance imaging-based oximetry. Background: Magnetic resonance imaging-based oximetry is a new calibration-free technique taking advantage of the paramagnetic nature of blood that depends on the volume fraction of deoxyhemoglobin in red blood cells. Methods: We compared post-occlusive blood oxygenation time-course of femoral/popliteal vessels in: 1) young healthy subjects (YH) (n = 10; mean ankle-brachial index [ABI] 1.0 ± 0.1, mean age 30 ± 7 years); 2) peripheral arterial disease (PAD) patients (n = 12; mean ABI 0.6 ± 0.1, mean age 71 ± 9 years); and 3) age-matched healthy control subjects (AHC) (n = 8; mean ABI 1.1 ± 0.1, mean age 68 ± 9 years). Blood oxygenation was quantified at 3.0-T field strength with a field mapping pulse sequence yielding the magnetic susceptibility difference between blood in the vessels and surrounding muscle tissue from which the intravascular blood oxygen saturation is computed as %HbO2. Results: Significantly longer washout time (42 ± 16 s vs. 14 ± 4 s; p < 0.0001) and lower upslope (0.60 ± 0.20 %HbO2/s vs. 1.32 ± 0.41 %HbO2/s; p = 0.0008) were observed for PAD patients compared with healthy subjects (YH and AHC combined). Furthermore, greater overshoot was observed in YH than in AHC (21 ± 8 %HbO2 vs. 10 ± 5 %HbO2; p = 0.0116). Conclusions: Post-occlusive transient changes in venous blood oxygenation might provide a new measure of vascular competence, which was found to be reduced in subjects with abnormal ABI, manifesting in prolonged recovery during the early phase of hyperemia.

Original languageEnglish (US)
Pages (from-to)598-606
Number of pages9
JournalJournal of the American College of Cardiology
Issue number6
StatePublished - Feb 9 2010


  • blood oxygen saturation
  • magnetic resonance oximetry
  • peripheral arterial disease
  • phase image
  • reactive hyperemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Evaluation of Cuff-Induced Ischemia in the Lower Extremity by Magnetic Resonance Oximetry'. Together they form a unique fingerprint.

Cite this